Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isoproterenol | requirement, beta-agonist, beta-adrenergic receptor as substrate | Homo sapiens | |
isoproterenol | requirement, beta-agonist, beta-adrenergic receptor as substrate | Bos taurus | |
platelet activating factor | requirement, agonist, beta-adrenergic receptor as substrate | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cDNA encoding beta-ARK 1 is cloned and sequenced, very similar sequences of bovine and human kinases | Homo sapiens |
cloning and sequencing | Homo sapiens |
very similar cDNA sequences of bovine and human kinases | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
heparin | - |
Bos taurus | |
heparin | rhodopsin phosphorylation, in a dose-dependent manner | Homo sapiens | |
additional information | - |
Bos taurus | |
additional information | not inhibited by protein kinase A inhibitor PKI; not inhibited by staurosporine | Homo sapiens | |
Protein kinase C inhibitor H7 | weak | Bos taurus | |
Protein kinase C inhibitor H7 | weak | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Bos taurus | 5829 | - |
cytosol | cytosolic enzyme, isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane | Homo sapiens | 5829 | - |
membrane | - |
Bos taurus | 16020 | - |
membrane | isoproterenol and platelet-activating factor induce translocation of beta-ARK from cytosol to membrane | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Homo sapiens | |
Mg2+ | requirement | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Homo sapiens | presumably modulates some receptor-mediated immune functions | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Homo sapiens | agonist-occupied form of the receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Bos taurus | agonist-occupied form of the receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Homo sapiens | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Bos taurus | involved in homologous desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
additional information | Homo sapiens | role for beta ARK in modulating some receptor-mediated immune functions | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2 | - |
Homo sapiens | - |
major isoform beta-ARK 1 | - |
Homo sapiens | - |
enzyme exists in 2 subtypes: beta-ARK1 and 2 | - |
Homo sapiens | P25098 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | moderate expression of beta-ARK 1 | Homo sapiens | - |
HL-60 cell | high expression of beta-ARK 1 | Homo sapiens | - |
IMR-32 cell | beta-ARK 1 | Homo sapiens | - |
JURKAT cell | high expression of beta-ARK 1 | Homo sapiens | - |
leukemia cell | myeloid and lymphoid leukemia cell lines, high expression of beta-ARK 1 | Homo sapiens | - |
leukocyte | - |
Bos taurus | - |
leukocyte | peripheral blood leukocytes | Homo sapiens | - |
leukocyte | mononuclear, peripheral blood leukocytes, high expression | Homo sapiens | - |
leukocyte | beta-ARK 1 | Homo sapiens | - |
MOLT-4 cell | high expression of beta-ARK 1 | Homo sapiens | - |
additional information | - |
Bos taurus | - |
additional information | tissue distribution of beta-ARK 1 | Homo sapiens | - |
U-937 cell | high expression of beta-ARK 1 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | presumably modulates some receptor-mediated immune functions | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | agonist-occupied form of the receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Homo sapiens | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | involved in homologous desensitization of beta-adrenergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + platelet-activating factor receptor | PAF receptor acts as substrate | Homo sapiens | ADP + phospho-platelet-activating factor receptor | - |
? | |
ATP + rhodopsin | light-dependent, actual substrate: light-bleached rhodopsin | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | light-dependent, actual substrate: light-bleached rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | in form of bovine rod outer segments | Homo sapiens | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | in form of bovine rod outer segments | Bos taurus | ADP + phosphorhodopsin | - |
? | |
additional information | role for beta ARK in modulating some receptor-mediated immune functions | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ark | - |
Homo sapiens |
beta-adrenergic receptor kinase 1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
7.4 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Bos taurus |